Iodoquinol associated seizures and radiopacity.

This case report describes seizures and encephalopathy in a nine year-old boy treated with iodoquinol for amebiasis. The toxicity of iodoquinol and other 8-hydroxyquinolines is discussed. The radiopacity of this medication, used worldwide for the treatment of diarrheal illnesses and dermatitis, may be diagnostically useful.

Tratamiento simplificado de la amebiasis intestinal con diyodohidroxiquinoleína en niños / A simplified treatment of intestinal amebiasis in children with diiodohydroxyquinolein

Se trataron con diyodohidroxiquinoleina 53 niños de ambos sexos, en edad comprendida entre cinco y 17 años, atendidos en la consulta externa del servicio de parasitología del Instituto Nacional de Pediatía, en los cuales se diagnosticó amebiasis intestinal no invasiva en fase clínica y por exámenes de laboratorio (CPS) Faust). El fármaco se administró a razón de 30 mg/kg/dpia 10 días. Hubo curación en el 98.1% sólo dos pacientes refirieron efectos advrsos atribuidos al medicamento, uno presentó diarrea y otro náusea. Los resultados obtenidos permiten recomendar el uso de diyodohidroxiquinoleína en el tratamiento de la amebiasis intestinal no invasiva en niños con un esquema más corto que el convencional, que disminuye la presentación de efectos adversos y abatimiento del costo

Nutritional effects of zinc on ocular and systemic physiology.

Zinc, an essential mineral in human nutrition, has multiple and complex ocular and systemic functions. Zinc deficiency is characterized by growth retardation, reduced appetite, skin changes, impaired reproductive development, impaired taste acuity, and impaired wound healing. Zinc deficiency may also cause or contribute to learning problems. Observations of Denver children have suggested that suboptimum zinc nutriture may be quite common in otherwise normal infants and children in the United States. The most likely cause of this deficiency is dietary insufficiency. High concentrations of zinc are found in human ocular tissues and are closely related to visual function. When zinc levels are inappropriately low, results can include ocular birth defects, reduced ability to dark adapt, excessively low IOP, and optic neuritis. Correction of zinc deficiency with zinc supplementation must be done cautiously because excessive zinc can interfere with the metabolism of copper and zinc.